Each capsule contains a LUPOSTROL® proprietary blend of citrus bioflavonoids, green pea and pumpkin powders and rice flour as a binding agent. No artificial colours, flavours or preservatives. Capsule shell: Gelatin

DOSAGE GUIDELINE OVERVIEW
A proposed dose is based on weight

For small dog breeds (up to 11kg): 1 capsule/day

For medium-sized dogs (12 - 34kg): 1 capsule, twice daily (BID)/day

For the larger dog breeds (over 35kg): 1 capsule, three times daily (TID)

For dogs of all sizes, you can also orally administer by adding to food, capsule contents can be emptied and mixed with the dog's food.

NESEM® represents over 25 years of dedicated research into understanding plant metabolites and employing cutting-edge extraction techniques to create food-based supplements of consistent performance and quality.

NESEM®
Naturally Elicited, Specifically Extracted, Molecules

"Naturally Elicited" - produced naturally in plants as a protection mechanism during the "ripening phase" in response to challenges in the environment of the plant as it grows ie attack by bacteria, virus or pathogens when not sprayed or modified.

"Specifically Extracted" - a targeted approach using supercritical fluid extraction to extract specific molecules from site of production, typically the skin and pith.

"Molecules" - phytonutrients found in high volumes in the pith and skin of ripening fruit or vegetables when attacked by pathogens/bacteria.

But what does this mean in practical terms?

When plants grow there are different phases of growth the plants undergo. The 1 st phase is the growth of the plant while the 2 nd Phase is when the plant flowers or fruits and ripens. It is at the end of this 2 nd phase of growth when the fruit is ripening that it is attacked by several pathogens, viruses, fungi etc. It is at this site of attack that the plant will provide or over-produce molecules (phytonutrients) to protect itself against this attack. We refer to these as molecules as secondary plant metabolites which occur at the site of attack or challenge, it is the plants natural defence system.

Natural supplements use some sort of extraction method to extract the plant molecules/extracts. Typically, solvents are used with alcohol being one of the major solvents used in practice. NPP use a targeted approach to extract specific molecules using super critical or sub critical fluid extraction methods.

Molecules are extracted from the pith and skin of the plants as this is where the concentration of the secondary plant metabolites are found, the site of attack.

Commercial cropping has reduced NESEM® extracts by:

• Creation of new varieties
• Picking produce green then shipping across to markets 
• Spraying of crops to reduce loss by disease etc 
• The use of fungicides or spraying in particular prelude the plant from having to produce these naturally protective compounds themselves as the chemicals used are providing the defence to the plant externally instead.
• Genetic modification to increase yields and reduce spoiling of crops 

Consumer demands for sweeter perfect looking produce has impacted the amount of NESEM® extracts we consume in our foods by:

• Sweet taste 
• Perfect produce – not quite ripe, no blemishes, storage methods
• Bright colours 
• Easy peel 
• Bigger produce

Remember if the plants are not being attacked, they are not producing these healing molecules or secondary plant metabolites in high concentrations.

Organically grown produce, is reported to contain higher amounts of these health-promoting compounds due to the exposure to naturally occurring challenges from plant pests to induce a defensive response and protective compounds, phytoalexins. However, the amount of these phytoalexins being produced and consumed is still unknown.

There is clearly potential to re optimise the levels of these molecules your intake from fruit and vegetable produce. The best way is to choose traditionally grown produce as these will increase the levels of secondary plant metabolites, phytoalexins/phytonutrients, but the exact intake is unclear as many factors such as growing methods, harvesting, storage etc can influence these levels.

Increase potential NESEM® content in your daily foods by: 

• Having a vege garden, growing your own produce. 
• Choose organic wherever possible. Shop at markets wherever possible. 
• Choose to eat in season as much as you are able. 
• Choose produce that has ripened on the plant if possible, rather than the shelf 

Unfortunately, many of our modern-day foods are conventionally grown with the use of sprays and pesticides, which result in much lower levels of these secondary plant metabolites or phytonutrients.

For the majority of the worlds population botanicals contain the largest source of life saving compounds. Humans can't produce these compounds that their bodies need to thrive and survive.

NESEM®extracts as nutritional factors

NESEM® as secondary plant metabolites, phytoalexins have been identified in many fruits, vegetables and herbs which are food sources around the world. They have been shown to benefit human health and have potent:

• Anti-cancer activities
• Neurogenesis functions
• Anti-inflammatory activities
• Antioxidant activities
• Cholesterol lowering ability

Among other benefits. These plant molecules possess key beneficial properties to human and animal health, wellbeing and quality of life.

NESEM® and diet deficiencies

NESEM® molecules have been identified and are generally found present in modern food sources, at significantly lower levels than those which would have been present in foods grown before the advent of modern agricultural pesticides, as little as 100 years ago when our diets were essentially organic.

Key reasons why NESEM® are deficient in the modern food supply

NESEM® extracts are generally bitter and now deliberately removed from foods in order to satisfy the modern desire for sweet flavours in foods The overuse of fungicides precludes the plant from having to produce these naturally protective molecules themselves as the chemicals used provide the defence to the plant externally instead. Modern agriculture limits the production of the health promoting molecules in our food supply. Traditionally grown foods on the other hand have been reported to contain higher levels of these health promoting molecules due to natural
exposure to challenges and pests that induce the defensive and protection molecule production at the site of attack within the pith and skin of our foods.

Modern agricultural practices also have a huge impact on soil make up and soil nutrient depletion, which in turn also leads to a reduction in the variety of insect species plus a reduced stimulus to produce NESEM®

The growing of crops all year, picking green out of season and shipping great distances to markets reduces the opportunistic ripening phase of our food supply on the plant, which is the time of the “attack” and production of these nesem® molecules.

NESEM® extracts or molecules and their health benefits

Given the consequences of the modern day diet, it is now essential that the levels of nesem® is maintained in both humans and animals.

Unfortunately this cannot be done easily by just choosing traditionally grown and heritage varieties and by adding naturally grown greens with bitter flavours to our diet. While this might clearly increase the levels which are consumed on a daily basis, the exact intake of nesem® will still be unclear, as many other factors such as source, variety, harvesting and storage of the crop as well as the way in which it has been grown will have an effect on the overall nesem® content.

What is so special about NESEM® technology from NPP?

Naturally Pure products (NPP) specialise in the research of botanical molecules and have screened many in the plant kingdom. Having performed the pant screening NPP will then identify the possible beneficial effects of these NESEM® through the validation of cell line research. To date NPP has extensive evidence that certain of these molecules

• Provide protection beyond anti-oxidants through a non anti-oxidant pathway
• Provide an anti aging effect
• Help modulate chronic diseases
• Modulate the inflammatory response
• Support neurogenesis

Powered by NESEM® Naturally elicited secondary plant metabolites (or phytoalexins) have been identified in many
fruits and vegetables and herbs, which are components of food sources around the world.